AUSTRiM presentation April, 2025
NHMRC CTC, The University of Sydney
Explaining
Prediction
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Primary outcome: Diabetes at two years, as measured by 2-hour glucose by OGTT \(\ge\) 11.1mmol/L
Wittert G, Bracken K, Robledo KP, et al. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): A randomised, double-blind, placebo-controlled, 2-year, phase 3b trial. The Lancet Diabetes & Endocrinology 2021;9:32–45. https://doi.org/10.1016/S2213-8587(20)30367-3
Intersection of missingness over risk factors in the 783 participants (all eligible cohort)
naniar::gg__miss_upset() function to plot the missingness using an upset plot
gtsummary::tbl_summary() function to summarise the data, combined with gtsummary::tbl_uvregression() to run univariate logistic regression models, merged together using gtsummary::tbl_merge()
Visualisation of coefficients from LASSO model, with all 33 risk factors included
model stability (add reference)
development of risk prediction models within individual patient data meta-analysis projects
explore changing risk factors over the clinical trial, and the effect on prediction
inference when there are non-proportional hazards